Born prior to 1700 in Ireland. He emigrated to America from Londonderry and settled in Kennett Township, Chester County, Pennsylvania. He probably came to America with his brothers John, Robert and Samuel in 1712, but the first record of him is in 1726 is on the Kennett Township tax roll. He left Chester County in 1729 and settled in Hopewell Township, Lancaster County (now Cumberland County) PA. He was an uncle or cousin of Joseph, Alex, and Samuel of Culbertson's Row. He died 1746 in Lancaster County. His son Samuel was his bondsman and administrator of his estate filed in 1746. His estate consisted of about 1900 acres, almost three square miles, and an inventory of his estate filed in 1747 showed its value to be $4,000, a very large sum for those days. Division of his estate was made in Cumberland County, in 1750, that named his children. He married in Chester County, Pennsylvania about 1720, Janet Breckenridge [H700], born about 1696 in Ireland. She was a sister to James Breckenridge. Several years after Andrew's death, Janet married John Miller.

From "Genealogy of the Culbertson and Culberson Families, who came to America before the year 1800." by Dr. Lewis Culbertson

1. Samuel Culbertson b: 1722 in Chester County, Pennsylvania
2. James Culbertson b: 1724 in Shippensburg, Pennsylvania
3. Andrew Culbertson , Jr. b: 1726 in Shippensburg, Pennsylvania
4. Elizabeth Culbertson b: ABT. 1728
5. Jane Culbertson b: 1730 in Pennsylvania
6. Martha Culbertson b: 1732 in Pennsylvania
7. Margaret Culbertson b: 1734 in Pennsylvania
8. Sarah Culbertson b: 1736 in Pennsylvania
9. Rebecca Culbertson b: 1738 in Pennsylvania
10. Robert Culbertson b: 1741 in Cumberland County, Pennsylvania